R. Guevara-Gonzalez 's Aflatoxins - Biochemistry and Molecular Biology PDF

By R. Guevara-Gonzalez

ISBN-10: 9533073950

ISBN-13: 9789533073958

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Example text

R G QP GG K NL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . T A G MS Y K Y F 192 192 138 67 50 51 51 84 290 290 229 157 126 127 127 159 383 383 322 248 216 217 217 252 438 438 378 311 278 284 284 351 Fig. 4. Comparison of A. flavus AflJ sequence to those of non-aflatoxin producing species reveals partial homology to methyltransferase-2 family proteins. The bracketed proteins have O-methyltransferase domains.

2005). The Aspergillus COP9 signalosome may control the abundance of the transcription factors that regulate these processes. , 2003) affects normal development in A. nidulans and pigmentation. In these mutants the abnormal mycelial pigmentation suggests that CSN regulates processes in both fungal development and secondary metabolism. When LaeA was used as the bait in a yeast two-hybrid assay with an A. parasiticus cDNA expression library as the prey, among the proteins binding to LaeA was COP9 signalosome complex subunit 5 (XM_001211499) (K.

2. The AF cluster for Aspergillus flavus, A. parasiticus and A. nomius. , 2004a). aflJ-aflR intergenic region BrlA aflJ AflR AflR PacC AbaA PacC tsp AbaA BrlA aflR cds G1-3 G4,5 G1-5=AreA-binding sites His-rich Pro-rich C6 cluster NLD Linker AflR protein Acidic domain Ser-rich His-Arg Poly-A 3’-untranslated region Fig. 3. Schematic depiction of the aflR gene. Consensus sequence elements for DNA-binding proteins are indicated on the aflJ-aflR intergenic region with their approximate positions. However, the aflR gene in each of the AF-producing species has fewer sites than those shown.

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Aflatoxins - Biochemistry and Molecular Biology by R. Guevara-Gonzalez

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